Identification of IS1R and IS10R elements inserted into ompk36 porin gene of two multidrug-resistant Klebsiella pneumoniae hospital strains

Klebsiella pneumoniae ST101 Clone Carrying an OmpK36 Porin Variant

Evaluation of Antimicrobial and Anti-biofilm Effects of Copper Nanoparticles Synthesized by Artemisia Scoparia Extract Against Multidrug-Resistant Klebsiella pneumoniae Strains and Analysis of Biofilm Gene Expression

Background: Klebsiella pneumoniae is one of the most important hospital opportunistic pathogens that have become resistant to many antibiotics due to biofilm formation. The aim of this study was to synthesize copper nanoparticles using Artemisia scoparia extract, to investigate its antimicrobial and anti-biofilm effects against K. pneumoniae strains. Methods: In this experimental study, 100 cli...

Synergistic effect of Thymbra spicata L. extracts with antibiotics against multidrug- resistant Staphylococcus aureus and Klebsiella pneumoniae strains

Objective(s): To evaluate the in vitro interaction between different extracts of Thymbra spicata L. and certain antimicrobial drugs of different mechanisms, including ampicillin, cefotaxime, amikacin and ciprofloxacin. This study was performed against multidrug-resistant strains of Staphylococcus aureus and Klebsiella pneumoniae. Materials and Methods: Evaluation of antibacterial activity and ...

Carbapenem and cefoxitin resistance of Klebsiella pneumoniae strains associated with porin OmpK36 loss and DHA-1 β-lactamase production

Clinical isolates of carbapenem-resistant Klebsiella pneumoniae (K. pneumoniae) strains are being increased worldwide. Five pan-resistant K. pneumoniae strains have been isolated from respiratory and ICU wards in a Chinese hospital, and reveal strong resistance to all β-lactams, fluoroquinolones and aminoglycosides. Totally 27 β-lactamase genes and 2 membrane pore protein (porin) genes in 5 K. ...

Prevalence of OmpK35 and OmpK36 porin expression in beta-lactamase and non-betalactamase- producing Klebsiella pneumoniae

BACKGROUND The aims of this study were to confirm the presence of OmpK35 and OmpK36 in extended-spectrum beta-lactamase-producing and nonextended-spectrum beta-lactamase-producing Klebsiella pneumoniae and to determine the relationship between porin expression and resistance to third-generation cephalosporins. METHODS Fifty-two K. pneumoniae isolates were obtained and analyzed for extended-sp...